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Orally administration of valsartan (1040 mg/kg/day, 4 weeks) promotes the hippocampus neurogenesis and the BDNF expression, exerting an antidepressant-like effect, which may be one of the mechanisms for its antidepressant (191)

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The disease burden, while showing a global decline in age-standardized incidence rates between 1990 and 2019, remains significant and continues to exhibit substantial geographic and demographic disparities, particularly in individuals aged 4064, the group with the highest incidence

2018;115:E2320E2328

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