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doi: 10.3390/biom13050799 238 PunzianoCTrombettiSCesaroEGrossoMFaraonioR

Apart from the PPP, two subtypes of isocitrate dehydrogenase (IDH) isoenzymes can also generate NADPH based on their intracellular localization: mitochondrial NADP + -dependent IDH ( Idh2 ), as well as cytosolic and peroxisomal NADP + -dependent ICDH ( Idh1 )

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Epub 2006 Oct 3

[1] [4] Kidney Problems : Notify your provider if you experience decreased urination, swelling in legs or feet, or unusual fatigue, as these may indicate kidney function changes, particularly in the setting of dehydration from gastrointestinal adverse effects