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Tesamorelin and GH Pulsatility Research Comparative studies of Tesamorelin and other GHRH analogues found that both peptides enhance overall GH exposure primarily by prolonging secretory episodes rather than increasing peak GH concentrations a distinction significant in experimental endocrinology, since sustained supraphysiological GH exposure can introduce confounding variables that pulsatile GHRH analogue models help to avoid

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At the experimental endpoints, mice were euthanized using inhaled isoflurane (5%, Panion & BF Biotech) in O 2 following approved ethical guidelines